Luteal Phase Defect Supplements: Vitamin B6, Vitex, and Progesterone Support
Luteal phase defect (LPD) accounts for 3-20% of infertility and recurrent early miscarriage cases, yet it remains controversial and often under-diagnosed. The luteal phase—the 12-16 day window between ovulation and menstruation—depends on adequate progesterone production from the corpus luteum to prepare the endometrium for implantation and support early pregnancy. When progesterone is insufficient or the luteal phase is too short (<10 days), implantation fails or early pregnancy loss occurs before a positive test registers.