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Hormone Replacement Therapy

GLP-1 Medications and Menopause Weight Loss: Does Ozempic Work Better During Perimenopause?

GLP-1 Medications and Menopause Weight Loss: Does Ozempic Work Better During Perimenopause? # The intersection of menopause and metabolic health creates unique challenges for women seeking weight loss. As estrogen levels decline during perimenopause and menopause, women experience an average weight gain of 5-7 pounds and a significant shift in fat distribution toward visceral (abdominal) adiposity.[1] GLP-1 receptor agonists like Ozempic (semaglutide), Wegovy (semaglutide), and Mounjaro (tirzepatide) have emerged as powerful tools for weight management, but their effectiveness and safety profile in menopausal women requires specific consideration. This comprehensive guide examines the clinical evidence, hormone interactions, and practical strategies for using GLP-1 medications during this critical life transition.