Methylation

Betaine, also known as trimethylglycine (TMG), is one of the most underrated yet scientifically validated supplements for methylation support, liver health, cardiovascular wellness, and athletic performance. Derived primarily from beets (Beta vulgaris, hence the name “betaine”), this naturally occurring compound serves as a critical methyl donor in one of your body’s most fundamental biochemical pathways. Unlike trendy supplements with limited research, betaine has decades of clinical evidence supporting its role in homocysteine metabolism, liver disease prevention, and cellular health optimization. It’s FDA-approved at high doses (6 grams daily) for treating homocystinuria, a genetic condition causing dangerous homocysteine buildup—proof of its safety and efficacy at therapeutic levels.